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You searched for: atherosclerosis in Cardiology
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A Weight-Loss Drug for Atherosclerosis? Free
- April 1, 2008
- Joel M. Gore, MD
- Cardiology
Rimonabant reduced some cardiovascular risk factors — but not disease progression — among obese patients in a prospective, placebo-controlled trial.- Reviewing:
- Nissen SE et al. for the STRADIVARIUS Investigators., JAMA 2008 Apr 2; 299:1547.
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Pioglitazone vs. Glimepiride for Atherosclerosis in Diabetes
- March 31, 2008
- Harlan M. Krumholz, MD, SM
- Cardiology
Pioglitazone comes out on top in this randomized trial, but we still need outcomes data.- Reviewing:
- Nissen SE et al. for the PERISCOPE Investigators., JAMA 2008 Apr 2; 299:1561.
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Beta-Blockers and Coronary Atherosclerosis Progression
- August 1, 2007
- Joel M. Gore, MD
- Cardiology
A pooled analysis of four intravascular ultrasonography trials suggests a benefit in patients with established coronary artery disease.
CME Exam- Reviewing:
- Sipahi I et al., Ann Intern Med 2007 Jul 3; 147:10-8.
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Torcetrapib Does Not Limit Atherosclerosis Progression Free
- March 26, 2007
- JoAnne M. Foody, MD
- Cardiology
Negative results from ILLUSTRATE follow the halting of ILLUMINATE.- Reviewing:
- Nissen SE et al. for the ILLUSTRATE Investigators., N Engl J Med 2007 Mar 29; 356:1304-16. Tall AR., N Engl J Med 2007 Mar 29; 356:1364-6.
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Cannabinoids Retard Progression of Atherosclerosis
- June 10, 2005
- Anthony L. Komaroff, MD
- Cardiology
Humans produce endogenous cannabinoid molecules and two receptors for cannabinoids, CB1 and CB2. The CB2 receptors are found predominantly on immune . . .- Reviewing:
- Steffens S et al., Nature 2005 Apr 7; 434:782-6. Roth MD., Nature 2005 Apr 7; 434:708-9.
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Statins, CRP, and Atherosclerosis Progression
- February 25, 2005
- Harlan M. Krumholz, MD, SM
- Cardiology
Are reductions in C-reactive protein (CRP) levels during statin therapy associated with reduced atherosclerosis progression, independent of the lowering of atherogenic lipoprotein levels? To find . . .- Reviewing:
- Nissen SE et al. for the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) Investigators., N Engl J Med 2005 Jan 6; 352:29-38.
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C-Reactive Protein and Atherosclerosis: No Case for Causality Free
- October 29, 2008
- Beat J. Meyer, MD
- Cardiology
But a genetics study confirms CRP’s role as a marker for cardiovascular events.
CME Exam- Reviewing:
- Zacho J et al., N Engl J Med 2008 Oct 30; 359:1897.
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Paraoxonase 1, Oxidative Stress, and Atherosclerosis
- March 19, 2008
- JoAnne M. Foody, MD
- Cardiology
A polymorphism of PON1 is found to have both biochemical and clinical associations with cardiovascular disease.- Reviewing:
- Bhattacharyya T et al., JAMA 2008 Mar 19; 299:1265.
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Statins Might Prevent Sepsis in Older Patients with Atherosclerosis
- March 9, 2006
- Bruce Soloway, MD
- Cardiology
A population-based analysis revealed significantly lower rates of sepsis with statin use; randomized trials would be required to determine whether statins might be used specifically to prevent sepsis.- Reviewing:
- Hackam DG et al., Lancet 2006 Feb 4; 367:413-8.
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COX-2 Could Explain Estrogen's Protection Against Atherosclerosis
- January 21, 2005
- Anthony L. Komaroff, MD
- Cardiology
The Women's Health Initiative (WHI) results convincingly showed that a particular combination of estrogen and progestin increased cardiovascular (CV) risk -- among women with an . . .- Reviewing:
- Egan KM et al., Science 2004 Dec 10; 306:1954-7.
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Treating Disease, Not Risk Factors
- June 9, 2010
- Joel M. Gore, MD
- Cardiology
Observational data suggest that using total carotid arterial plaque burden to guide therapy can improve markers of atherosclerotic disease.- Reviewing:
- Spence JD and Hackam DG., Stroke 2010 Jun; 41:1193.
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Nothing Captivating About Acyl–Coenzyme A:Cholesterol Acyltransferase Inhibition
- March 25, 2009
- JoAnne M. Foody, MD
- Cardiology
Findings from an atherosclerosis progression study squelch the clinical prospects of yet another cholesterol-targeting agent.- Reviewing:
- Meuwese MC et al., JAMA 2009 Mar 18; 301:1131.
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Aggressive Treatment of High LDL Levels and Hypertension in Patients with Diabetes Free
- April 8, 2008
- JoAnne M. Foody, MD
- Cardiology
Three-year results from SANDS supply much-needed information but no definitive answer to the question of how low to set targets in primary prevention of CVD.- Reviewing:
- Howard BV et al., JAMA 2008 Apr 9; 299:1678.
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METEOR: Does Rosuvastatin Benefit Low-Risk Patients? Free
- April 4, 2007
- JoAnne M. Foody, MD
- Cardiology
The drug slowed progression of carotid intima-media thickness, but cardiovascular outcomes were not assessed.- Reviewing:
- Crouse JR III et al. for the METEOR Study Group., JAMA 2007 Mar 28; 297:1344-53. Lauer MS., JAMA 2007 Mar 28; 297:1376-8.
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Negative Findings for ACAT Inhibition
- April 27, 2006
- Harlan M. Krumholz, MD, SM
- Cardiology
Pactimibe did not inhibit atherosclerosis progression.- Reviewing:
- Nissen SE et al. for the ACAT Intravascular Atherosclerosis Treatment Evaluation (ACTIVATE) Investigators., N Engl J Med 2006 Mar 23; 354:1253-63. Fazio S and Linton M., N Engl J Med 2006 Mar 23; 354:1307-9.
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Inflammation and Cardiovascular Disease in RA
- April 13, 2006
- Richard Saitz, MD, MPH, FACP, FASAM
- Cardiology
The prevalence of atherosclerosis was significantly greater in patients with RA than in controls.- Reviewing:
- Roman MJ et al., Ann Intern Med 2006 Feb 21; 144:249-56.
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Statins May Prevent Blocked Veins as Well as Blocked Arteries
- September 14, 2011
- Joel M. Gore, MD
- Cardiology
Atherosclerosis patients who received statins or antiplatelets had a lower incidence of VTE than those who did not, and the statin effect appeared to be dose-related.- Reviewing:
- Khemasuwan D et al., Am J Med 2011 Sep; 124:852.
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C-Reactive Protein: Shooting at the Messenger?
- July 1, 2009
- JoAnne M. Foody, MD
- Cardiology
Findings from a genomewide association and Mendelian randomization study suggest that CRP is a marker, not a cause, of atherosclerosis.
CME Exam- Reviewing:
- Elliott P et al., JAMA 2009 Jul 1; 302:37. Shah SH and de Lemos JA., JAMA 2009 Jul 1; 302:92.
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Top Cardiology Stories of 2008 Free
- December 10, 2008
- Harlan M. Krumholz, MD, SM
- Cardiology
. . .selected by the physician-editors of Journal Watch Cardiology -
Is Carotid Plaque a Predictor of Vascular Events?
- April 9, 2008
- Joel M. Gore, MD
- Cardiology
In an observational study, a simple, noninvasive marker of subclinical atherosclerosis added predictive power to the Framingham Risk Score.- Reviewing:
- Rundek T et al., Neurology 2008 Apr 1; 70:1200.
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