Genetic Causes of Cardiac Hypertrophy
Summary and Comment Subscription required
An analysis of affected children identifies mutations in several genes previously implicated in adult-onset disease.
A New Drug-Eluting Stent on the Horizon
Summary and Comment Subscription required
Everolimus-eluting stents perform well in a comparison with paclitaxel-eluting stents, setting the stage for FDA approval and — more important — long-term outcome studies.
By Howard C. Herrmann, MD
May 7, 2008
Covering:
Stone GW et al., JAMA 2008 Apr 23; 299:1903
Patel MR and Holmes DR Jr., JAMA 2008 Apr 23; 299:1952
Are High-Dose Tirofiban and Drug-Eluting Stents Best for STEMI?
Summary and Comment Subscription required
Results of a randomized study favor SES over BMS and show a high-dose bolus of tirofiban to be as good as abciximab.
Prophylactic Implantable Cardioverter-Defibrillators?
Summary and Comment Subscription required
A finding that inappropriate ICD shocks are associated with increased mortality raises a chicken-or-egg question.
By Mark S. Link, MD
April 30, 2008
Covering:
Daubert JP et al., J Am Coll Cardiol 2008 Apr 8; 51:1357
Raitt MH., J Am Coll Cardiol 2008 Apr 8; 51:1366
Percutaneous Coronary Intervention Reduces Ischemia in COURAGE Substudy
Summary and Comment Subscription required
Myocardial perfusion scintigraphy measurements before and after optimal medical therapy with or without PCI suggest that residual ischemia may affect CAD prognosis.
Do Disease Management Programs Really Make a Difference in Heart Failure?
Summary and Comment Subscription required
A randomized trial of three programs of varying intensity did not reveal any significant differences in outcomes.
By William T. Abraham, MD
April 23, 2008
Covering:
Jaarsma T et al. for the COACH Investigators., Arch Intern Med 2008 Feb 11; 168:316
Diminishing the Flush of Niacin
Summary and Comment Subscription required
Results of a small study suggest that adding a prostaglandin D2 antagonist may render niacin more tolerable for treating lipid disorders in many patients.
By Joel M. Gore, MD
April 23, 2008
Covering:
Paolini JF et al., Am J Cardiol 2008 Mar 1; 101:625
Prasugrel vs. Clopidogrel, Continued . . .
Summary and Comment Subscription required
A subanalysis of TRITON-TIMI 38 suggests that prasugrel lowers stent thrombosis rates in high-risk ACS patients.
By Beat J. Meyer, MD
April 23, 2008
Covering:
Wiviott SD et al. for the TRITON-TIMI 38 Investigators., Lancet 2008 Apr 19; 371:1353
Ajani AE and Lefkovits J., Lancet 2008 Apr 19; 371:1315
Guidelines: MI and Chest Pain Associated with Cocaine Use
Clinical Practice Guideline Watch Subscription required
A scientific statement summarizes urgent and nonurgent care of a subgroup of chest-pain patients with unique characteristics.
By Mark S. Link, MD
April 16, 2008
Covering:
McCord J et al., Circulation 2008 Apr 8; 117:1897
MC-1 Fails to Improve Outcomes of Coronary Artery Bypass Grafting
Summary and Comment Subscription required
Another promising agent to protect against ischemia-reperfusion injury disappoints in a phase III trial.
By JoAnne M. Foody, MD
April 16, 2008
Covering:
MEND-CABG II Investigators., JAMA 2008 Apr 16; 299:1777
